One dead after poop transplant gone wrong, FDA warns

The Food and Drug Administration headquarters in White Oak, Md.

Enlarge / The Food and
Drug Administration headquarters in White Oak, Md. (credit:

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)

One patient has died and another became seriously ill after
fecal transplants inadvertently seeded their innards with a
multi-drug resistant bacterial infection,
the Food and Drug Administration warned Thursday.

The cases highlight the grave risks of what some consider a
relatively safe procedure. They also flush out the mucky issues of
federal oversight for the experimental transplants, which the FDA
has strained to regulate. In its warning Thursday, the agency
announced new protections for trials and experimental uses of the
procedure.

The FDA shared minimal details from the deadly transplants. Its
warning only noted that the cases involved two patients who were
immunocompromised prior to the experimental transplants and
received stool from the same donor. Subsequent to the transplant,
the patients developed invasive infections from an E. coli strain
that was resistant to a wide variety of antibiotics in the
penicillin and cephalosporin groups. The E. coli strain carried a
drug-defeating enzyme called an
extended-spectrum beta-lactamase
(ESBL), which generally
cleaves a ring common to all the chemical structures of those
antibiotics.. When unnamed researchers who administered the
transplant looked back at the donor stool, they found that the
stool contained an identical ESBL-producing E. coli.

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Source: FS – All – Science – News
One dead after poop transplant gone wrong, FDA warns